Nefiracetam Attenuates Pro-Inflammatory Cytokines and GABA Transporter in Specific Brain Regions of Rats with Post-Ischemic Seizures

@article{Fu2015NefiracetamAP,
  title={Nefiracetam Attenuates Pro-Inflammatory Cytokines and GABA Transporter in Specific Brain Regions of Rats with Post-Ischemic Seizures},
  author={Chuanyi Fu and Xu-ying He and Xi-feng Li and X. Zhang and Z. Huang and J. Li and M. Chen and C. Duan},
  journal={Cellular Physiology and Biochemistry},
  year={2015},
  volume={37},
  pages={2023 - 2031}
}
Background/Aims: Prior studies demonstrated that pro-inflammatory cytokines (PICs) including IL-1β, IL-6 and TNF-α contribute to regulation of epilepsy-associated pathophysiological processes in the specific brain regions, namely the parietal cortex, hippocampus and amygdala. Moreover, GABA transporter type 1 and 3 (GAT-1 and GAT-3) modulating extracellular GABA levels are engaged in the role played by PICs in epileptogenesis. Note that brain ischemic injury also elevates cerebral PICs. Thus… Expand
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