Nefazodone: preclinical pharmacology of a new antidepressant.

  title={Nefazodone: preclinical pharmacology of a new antidepressant.},
  author={A. S. Eison and Michael S. Eison and John R Torrente and Richard N. Wright and Frank D. Yocca},
  journal={Psychopharmacology bulletin},
  volume={26 3},
Recent pharmacologic studies suggest that nefazodone may possess antidepressant activity. Nefazodone is active in behavioral models predictive of antidepressant potential. It is active in reversing learned helplessness, prevents reserpine-induced ptosis, and enhances response efficiency in the differential reinforcement for low rates of response paradigm. In in vitro studies, nefazodone inhibits the binding of [3H]ketanserin to cortical serotonin2 (5-HT2) binding sites, whereas in vivo, it… CONTINUE READING
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