Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions

@article{Moltke1999NefazodoneMA,
  title={Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions},
  author={Lisa L. von Moltke and David J Greenblatt and Brian W. Granda and Jeffrey M. Grassi and Juergen Schmider and Jerold S. Harmatz and Richard Irwin Shader},
  journal={Psychopharmacology},
  year={1999},
  volume={145},
  pages={113-122}
}
Rationale: Understanding of the mechanisms of biotransformation of antidepressant drugs, and of their capacity to interact with other medications, is of direct relevance to rational clinical psychopharmacology. Objectives: To determine the human cytochromes P450 mediating the metabolism of nefazodone, and the inhibitory activity of nefazodone and metabolites versus human P450–3A. Methods: Biotransformation of nefazodone to its metabolic products, and of meta-chlorophenylpiperazine (mCPP) to… CONTINUE READING
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