Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors.

@article{Kirchhoff2004NefPF,
  title={Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors.},
  author={Frank Kirchhoff and Michael Schindler and Nicola Bailer and G Herma Renkema and Kalle Saksela and Volker Knoop and Michaela M{\"u}ller-Trutwin and Mario L Santiago and Fr{\'e}d{\'e}ric Bibollet-Ruche and Matthias T. Dittmar and Jonathan Luke Heeney and Beatrice H. Hahn and Jan M{\"u}nch},
  journal={Journal of virology},
  year={2004},
  volume={78 13},
  pages={6864-74}
}
The accessory Nef protein allows human immunodeficiency virus type 1 (HIV-1) to persist at high levels and to cause AIDS in infected humans. The function of HIV-1 group M subtype B nef alleles has been extensively studied, and a variety of in vitro activities believed to be important for viral pathogenesis have been established. However, the function of nef alleles derived from naturally simian immunodeficiency virus (SIV)-infected chimpanzees, the original host of HIV-1, or from the HIV-1 N… CONTINUE READING

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