Nef protein of HIV‐1 has B‐cell stimulatory activity

@article{Chirmule1994NefPO,
  title={Nef protein of HIV‐1 has B‐cell stimulatory activity},
  author={Narendra Chirmule and Naoki Oyaizu and Carl W. Saxinger and Savita Pahwa},
  journal={AIDS},
  year={1994},
  volume={8},
  pages={733–740}
}
ObjectiveTo examine the B-cell stimulatory properties of the regulatory Nef protein of HIV-1. MethodsThe effect of the HIV-1 regulatory proteins Nef, Tat and Vif, were analyzed for their ability to induce differentiation of normal B lymphocytes into immunoglobulin secreting cells (ISC). ResultsA recombinant Nef protein, but neither Tat or Vif, was able to induce ISC in peripheral blood lymphocyte (PBL) cultures of HIV-1-seronegative donors. Another recombinant Nef protein, d-Nef, with a… Expand
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  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
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