Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism.

@article{Papkalla2002NefEH,
  title={Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism.},
  author={Armin Papkalla and Jan M{\"u}nch and Claas Otto and Frank Kirchhoff},
  journal={Journal of virology},
  year={2002},
  volume={76 16},
  pages={8455-9}
}
We investigated the infectivities and replicative capacities of a large panel of variants of the molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively in the V3 region of the viral envelope glycoprotein and the nef gene. Our results demonstrate that Nef enhances virion infectivity and HIV-1 replication independently of the viral coreceptor tropism. 

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