Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

@article{Schindler2006NefMediatedSO,
  title={Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1},
  author={Michael Schindler and Jan M{\"u}nch and Olaf Kutsch and Hui Li and Mario L. Santiago and Frédéric Bibollet-Ruche and Michaela M{\"u}ller-Trutwin and Francis J. Novembre and Martine Peeters and Val{\'e}rie Courgnaud and Elizabeth Bailes and Pierre Roques and Donald L Sodora and Guido Silvestri and Paul M. Sharp and Beatrice H. Hahn and Frank Kirchhoff},
  journal={Cell},
  year={2006},
  volume={125},
  pages={1055-1067}
}
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It is demonstrated that HIV-1 infection in activated CD4(+) T cells was followed by Nef-mediated downregulation of CTLA-4, which highlights the propensity of HIV- 1 to evade restriction of the key negative immune regulator CTla-4 on cell activation and viral replication, and therefore contributes to the overall HIV-2 pathogenesis.

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