Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

@article{Schindler2006NefMediatedSO,
  title={Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1},
  author={M. Schindler and J. M{\"u}nch and O. Kutsch and H. Li and M. Santiago and F. Bibollet-Ruche and M. M{\"u}ller-Trutwin and F. Novembre and M. Peeters and V. Courgnaud and E. Bailes and P. Roques and D. Sodora and G. Silvestri and P. Sharp and B. Hahn and F. Kirchhoff},
  journal={Cell},
  year={2006},
  volume={125},
  pages={1055-1067}
}
High-level immune activation and T cell apoptosis represent a hallmark of HIV-1 infection that is absent from nonpathogenic SIV infections in natural primate hosts. The mechanisms causing these varying levels of immune activation are not understood. Here, we report that nef alleles from the great majority of primate lentiviruses, including HIV-2, downmodulate TCR-CD3 from infected T cells, thereby blocking their responsiveness to activation. In contrast, nef alleles from HIV-1 and a subset of… Expand
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395 Citations

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