Needles in the Haystack: Identifying Individuals Present in Pooled Genomic Data

@inproceedings{Braun2009NeedlesIT,
  title={Needles in the Haystack: Identifying Individuals Present in Pooled
                    Genomic Data},
  author={Rosemary Braun and William L. Rowe and Carl G. Schaefer and Jinghui Zhang and Kenneth H. Buetow},
  booktitle={PLoS genetics},
  year={2009}
}
Recent publications have described and applied a novel metric that quantifies the genetic distance of an individual with respect to two population samples, and have suggested that the metric makes it possible to infer the presence of an individual of known genotype in a sample for which only the marginal allele frequencies are known. However, the assumptions, limitations, and utility of this metric remained incompletely characterized. Here we present empirical tests of the method using publicly… CONTINUE READING
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