Needle-free Biojector injection of a dengue virus type 1 DNA vaccine with human immunostimulatory sequences and the GM-CSF gene increases immunogenicity and protection from virus challenge in Aotus monkeys.

@article{Raviprakash2003NeedlefreeBI,
  title={Needle-free Biojector injection of a dengue virus type 1 DNA vaccine with human immunostimulatory sequences and the GM-CSF gene increases immunogenicity and protection from virus challenge in Aotus monkeys.},
  author={Kanakatte Raviprakash and Dan Ewing and Monika Simmons and Kevin Randall Porter and Trevor R. Jones and Curtis G. Hayes and Richard Stout and Gerald S. Murphy},
  journal={Virology},
  year={2003},
  volume={315 2},
  pages={345-52}
}
A dengue-1 DNA vaccine containing sequences encoding premembrane and envelope proteins (DIME) was previously shown to elicit virus neutralizing antibodies in rhesus and Aotus monkeys, and the primates were partially protected from viremia upon challenge. To increase the neutralizing antibody levels and subsequent protection from virus challenge, four strategies were evaluated: (a) coimmunization with a plasmid expressing Aotus GM-CSF gene; (b) coimmunization with a plasmid containing human… CONTINUE READING

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