Needed: pragmatic clinical trials for statin-intolerant patients.

  title={Needed: pragmatic clinical trials for statin-intolerant patients.},
  author={Patricia Maningat and Jan L. Breslow},
  journal={The New England journal of medicine},
  volume={365 24},
S are the most commonly prescribed drugs for lowering low-density lipoprotein (LDL) cholesterol levels. They’ve been amply studied in phase 3, randomized clinical trials and have been shown in primary and secondary prevention trials to reduce the risk of cardiovascular events. Statin use has increased dramatically in the past decade and will probably increase further because of lowered LDL cholesterol goals, new indications for treatment (increased C-reactive protein levels despite low or… CONTINUE READING
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