Need for reassessment of reported CYP2C19 allele frequencies in various populations in view of CYP2C19*17 discovery: the case of Greece.

@article{Ragia2009NeedFR,
  title={Need for reassessment of reported CYP2C19 allele frequencies in various populations in view of CYP2C19*17 discovery: the case of Greece.},
  author={Georgia Ragia and Kostas I Arvanitidis and Anna Tavridou and Vangelis G. Manolopoulos},
  journal={Pharmacogenomics},
  year={2009},
  volume={10 1},
  pages={43-9}
}
INTRODUCTION CYP2C19*17 is a novel variant allele causing ultrarapid metabolism of CYP2C19 substrates. In the present study we investigated the CYP2C19*17 allelic frequency and recalculated previously reported frequencies of the CYP2C19*1/*1 genotype and of all genotype-derived phenotypes for CYP2C19 in the Greek population. MATERIALS & METHODS A total of 283 nonrelated healthy Greek ethnic subjects that had already been genotyped for CYP2C19*2 and *3 alleles as well as for CYP2D6 and CYP2C9… CONTINUE READING

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