Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

@article{Brill1987NeedFD,
  title={Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA},
  author={Steven J. Brill and Stephen DiNardo and Karen Voelkel-Meiman and Rolf Sternglanz},
  journal={Nature},
  year={1987},
  volume={326},
  pages={414-416}
}
Yeast strains with mutations in the genes for DNA topoisomerases I and II have been identified previously in both Saccharomyces cerevisiae1–3 and Schizosaccharomyces pombe4. The topoisomerase II mutants (top2) are conditional-lethal temperature-sensitive (ts) mutants. They are defective in the termination of DNA replication and the segregation of daughter chromosomes2–5, but otherwise appear to replicate and transcribe DNA normally. Topoisomerase I mutants (top1), including strains with null… CONTINUE READING

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