Nedocromil sodium inhibits responsiveness to inhaled mannitol in asthmatic subjects.

Abstract

Nedocromil sodium inhibits the response to exercise-induced asthma (EIA). Mannitol given as a powder by inhalation is an osmotic stimulus that identifies EIA. We studied the acute effect of nedocromil on airway responsiveness to mannitol in 24 asthmatic subjects. After a control day, nedocromil (8 mg) or its placebo was administered randomized, double blind, 10 min before a challenge with progressively increasing doses of mannitol. Nedocromil inhibited the response to mannitol and there was a significant increase in the dose of mannitol required to cause a 15% reduction in FEV(1) (PD(15)) after nedocromil 409 (316,503) mg compared with placebo 156 (106,229) mg (p < 0.001). In the presence of nedocromil 12 subjects no longer recorded a 15% decrease in FEV(1) in response to mannitol. The remaining 12 required a significantly greater dose of mannitol to achieve a 15% decrease in FEV(1) after nedocromil. Following nedocromil, a plateau in responsiveness to mannitol was observed in 14 subjects. Nedocromil significantly inhibits the responsiveness to inhaled mannitol in asthmatic subjects.

Statistics

02040'02'04'06'08'10'12'14'16
Citations per Year

85 Citations

Semantic Scholar estimates that this publication has 85 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Brannan2000NedocromilSI, title={Nedocromil sodium inhibits responsiveness to inhaled mannitol in asthmatic subjects.}, author={J. Brannan and Sandra Doreen Anderson and Ruth Freed and J{\"{o}rg Daniel Leuppi and Heikki Olavi Koskela and H. K. Chan}, journal={American journal of respiratory and critical care medicine}, year={2000}, volume={161 6}, pages={2096-9} }