Nedocromil sodium in obstructive airways disease: effect on symptoms and plasma protein leakage in sputum.

  title={Nedocromil sodium in obstructive airways disease: effect on symptoms and plasma protein leakage in sputum.},
  author={D. Schoonbrood and T. Out and A. Hart and F. Habets and C. Roos and H. Jansen},
  journal={The European respiratory journal},
  volume={10 7},
In patients with asthma or chronic obstructive pulmonary disease, there is chronic airway inflammation with increased leakage of plasma proteins into the airway lumen, which can be reduced by inhaled glucocorticosteroids. Nedocromil sodium is an anti-inflammatory drug, and we questioned whether it also affects the leakage of plasma proteins. In a double-blind placebo-controlled study we investigated the effect of 12 weeks of treatment with nedocromil on forced expiratory volume in one second… Expand
6 Citations
Effect of cetirizine dihydrochloride on the airway response to hypertonic saline aerosol in patients with chronic obstructive pulmonary disease (COPD).
The present data indicate some, though small, effects of the H1 receptor antagonist cetirizine on hypertonic saline-induced airway obstruction in patients with moderate-to-severe COPD. Expand
Methodological aspects in the analysis of spontaneously produced sputum.
  • T. Out, H. Jansen, R. Lutter
  • Medicine
  • Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
  • 2001
Critically review the procedures for collecting spontaneously produced sputum, for handling the samples, and the requirements for assay of spUTum components to imply the reproducibility of the analysis, the recovery of solutes, the validity of assays in terms of reproduCibility and of linearity of the response, the usefulness of assay with respect to their response upon treatment of patients. Expand
Chapter 60 – Other Therapies
This chapter examines the various vaccines and antiviral agents used for the treatment of asthma and chronic obstructive pulmonary disease and reports that inactivated vaccine reduces the rate of exacerbations. Expand
Effect of budesonide and nedocromil sodium on IL-6 and IL-8 release from human nasal mucosa and polyp epithelial cells.
The different effect of budesonide and nedocromil sodium on IL-6 and IL-8 release may be explained by differences in the mechanisms which regulate the upregulation of these cytokines in inflammatory responses. Expand
Effect of nedocromil sodium on non-adrenergic, non-cholinergic neural responses in guinea pig bronchi in vitro
Nedocromil exerts selective neural inhibition of the contractile but not of the relaxant NANC responses on a pre-junctional level in bronchial smooth muscle and does not markedly impair the ability of NANC response to stabilise bronchia smooth muscle tone. Expand
Mast Cell Stabilizing Drugs
C Cromolyn sodium (sodium cromoglycate, SCG) and nedocromil sodium, traditionally referred to as mast cell stabilizing agents, comprise an important group of mild to moderate anti-inflammatory drugs. Expand


Effects of nedocromil sodium in the treatment of non-allergic subjects with chronic obstructive pulmonary disease.
Longer trials will be necessary to assess if nedocromil sodium can reduce the frequency of exacerbations and the decrease in pulmonary function, eventually leading to a better quality of life in patients with COPD. Expand
Plasma protein leakage and local secretion of proteins assessed in sputum in asthma and COPD. The effect of inhaled corticosteroids.
Sputum analysis is useful to study the local inflammatory process in asthma and COPD, and whether inflammatory markers in sputum are affected by treatment. Expand
Analysis of plasma-protein leakage and local secretion in sputum from patients with asthma and chronic obstructive pulmonary disease.
In patients with asthma, the plasma-protein leakage, as measured with the RCE in SSP, appears to correlate with indirect indices of airway inflammation, and the usefulness of sputum analysis is concluded. Expand
Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma. Effects of therapy with inhaled steroids.
The results show that in patients with stable asthma, there is an increased plasma exudation into the airways, most likely caused by an increased respiratory membrane permeability. Expand
Effects of nedocromil sodium on allergen-induced rhinitis in humans.
This protocol revealed that two topical 130 microliter doses of a 1% solution of NS failed to significantly reduce allergen-induced symptoms, PGD2 generation, or secretion of albumin, IgG, or lactoferrin when NS was compared with placebo. Expand
Effect of corticosteroids on sputum sol-phase protease inhibitors in chronic obstructive pulmonary disease.
The sputum-to-serum ratio of alpha 1-antichymotrypsin rose during steroid treatment with the result that there was a selective increase in this protease inhibitor, which may be of potential benefit to patients with chronic obstructive bronchitis. Expand
Asthma symptoms and airway hyperresponsiveness are lower during treatment with nedocromil sodium than during treatment with regular inhaled albuterol.
Regular treatment with nedocromil sodium led to greater asthma symptom control and reduced bronchial responsiveness compared with regular treatment with albuterol, and the study showed that more frequent use of a beta 2-agonist did not improve asthma control. Expand
Effects of methylprednisolone on sputum biochemical components in asthmatic bronchitis.
Nineteen patients with chronic mucus hypersecretion and reversible airway obstruction were studied during an acute exacerbation with gradually decreasing doses of methylprednisolone, suggesting a marked IgG serum exudation. Expand
Effect of nedocromil on bronchospasm induced by inhalation of substance P in asthmatic subjects
It is demonstrated that inhalation of substance P causes a dose‐dependent bronchoconstriction and that the bronchospasm induced by substance P can be prevented by pre‐treatment with nedocromil sodium. Expand
Protective effects of nedocromil sodium on cellular and biohumoral components present in the bronchial alveolar lavage fluid and in peripheral blood in atopic asthmatics.
It is demonstrated that nedocromil sodium prevents the release of chemotactic and inflammatory mediators by the effector cells and thus stabilizes microvascular permeability and epithelial damage, so raising the threshold of response to bronchoconstriction stimuli. Expand