Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

@inproceedings{Platta2012Nedd4dependentLP,
  title={Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1},
  author={Harald W. Platta and Hilde Abrahamsen and Sigrid B. Thoresen and Harald Stenmark},
  booktitle={The Biochemical journal},
  year={2012}
}
Beclin 1, a subunit of the class III phosphatidylinositol 3-kinase complex, is a tumour suppressor with a central role in endocytic trafficking, cytokinesis and the cross-regulation between autophagy and apoptosis. Interestingly, not only reduced expression but also overexpression of Beclin 1 is correlated with cancer development and metastasis. Thus it seems necessary for the cell to balance the protein levels of Beclin 1. In the present study we describe a regulatory link between Beclin 1 and… CONTINUE READING
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