Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma

@inproceedings{Bevelacqua2012NectinLO,
  title={Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma},
  author={Valentina Bevelacqua and Ylenia Bevelacqua and Saverio Candido and Evangelia Skarmoutsou and Alfredo Amoroso and Claudio Guarneri and Angela Strazzanti and Pietro Gangemi and Maria Clorinda Mazzarino and Fabio D'Amico and James A McCubrey and Massimo Libra and Grazia Malaponte},
  booktitle={Oncotarget},
  year={2012}
}
NECL-5 is involved in regulating cell-cell junctions, in cooperation with cadherins, integrins and platelet-derived growth factor receptor, that are essential for intercellular communication. Its role in malignant transformation was previously described. It has been reported that transformation of melanocytes is associated with altered expression of adhesion molecules suggesting the potential involment of NECL-5 in melanoma development and prognosis. To shed light on this issue, the expression… CONTINUE READING

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