Nectin and afadin: novel organizers of intercellular junctions.

  title={Nectin and afadin: novel organizers of intercellular junctions.},
  author={Yoshimi Takai and Hiroyuki Nakanishi},
  journal={Journal of cell science},
  volume={116 Pt 1},
The cadherin superfamily plays key roles in intercellular adhesion. An emerging intercellular adhesion system, consisting of nectin and afadin, also has roles in organization of a variety of intercellular junctions either in cooperation with, or independently of, cadherin. Nectin is a Ca(2+)-independent immunoglobulin-like intercellular adhesion molecule, and afadin is a nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. This novel intercellular adhesion… CONTINUE READING
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Afadin : a novel actin filamentbinding protein with one PDZ domain localized at cadherinbased celltocell adherens junction

  • K. Mandai, H. Nakanishi, +7 authors T. Fujimoto
  • J . Cell Biol .
  • 1997
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