Nectin-2 and DDX3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder.

@article{Miao2013Nectin2AD,
  title={Nectin-2 and DDX3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder.},
  author={Xiongying Miao and Zhu-lin Yang and Li Xiong and Qiong Zou and Yuan Yuan and Jinghe Li and Lufeng Liang and Meigui Chen and Senlin Chen},
  journal={International journal of clinical and experimental pathology},
  year={2013},
  volume={6 2},
  pages={179-90}
}
The clinicopathological and biological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) of gallbladder have not been well documented because it is a rare subtype of gallbladder cancer. In this study, the protein expression of Nectin-2 and DDX3 in 46 SC/ASCs and 80 adenocarcinomas was measured using immunohistochemistry. We demonstrated that positive Nectin-2 and DDX3 expression was significantly associated with large tumor size, high TNM stage, and lymph node metastasis of SC… CONTINUE READING