Necrotizing leukoencephalopathy associated with nonconvulsive status epilepticus and periodic short-interval diffuse discharges: a clinicopathological study.

@article{FernndezTorre2006NecrotizingLA,
  title={Necrotizing leukoencephalopathy associated with nonconvulsive status epilepticus and periodic short-interval diffuse discharges: a clinicopathological study.},
  author={Jos{\'e} L Fern{\'a}ndez-Torre and Fritzie Arce and M {\'A}ngeles Mart{\'i}nez-Mart{\'i}nez and Jes{\'u}s Gonz{\'a}lez-Rato and Jon Infante and Jesus Higuera Calleja},
  journal={Clinical EEG and neuroscience},
  year={2006},
  volume={37 1},
  pages={50-3}
}
We describe the clinical, neuroimaging and neuropathological features of an immunocompromised patient diagnosed as having refractory nonconvulsive status epilepticus (NCSE), and whose consecutive electroencephalograms (EEGs) revealed persistent periodic short-interval diffuse discharges (PSIDDs). Prominent subcortical white matter lesions in keeping with the diagnosis of multifocal necrotizing leukoencephalopathy may be neuropathological substrate of NCSE with persistent PSIDDs.