Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles.

  title={Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles.},
  author={Loren G. Miller and Françoise Perdreau-Remington and Gunter K. Rieg and Sheherbano Mehdi and Joshua Perlroth and Arnold S Bayer and Angela W. Tang and Tieu O Phung and Brad Spellberg},
  journal={The New England journal of medicine},
  volume={352 14},
BACKGROUND Necrotizing fasciitis is a life-threatening infection requiring urgent surgical and medical therapy. Staphylococcus aureus has been a very uncommon cause of necrotizing fasciitis, but we have recently noted an alarming number of these infections caused by community-associated methicillin-resistant S. aureus (MRSA). METHODS We reviewed the records of 843 patients whose wound cultures grew MRSA at our center from January 15, 2003, to April 15, 2004. Among this cohort, 14 were… 

Figures from this paper

Necrotizing Fasciitis Caused by Staphylococcus aureus: The Emergence of Methicillin-Resistant Strains

S. aureus is an important pathogen of monomicrobial necrotizing fasciitis, and MRSA has emerged as the predominant causative agent in recent years, therefore, MRSA-directed antibiotic therapy should be considered when treating patients suspected with necrotized fAsciitis in endemic areas.

Necrotizing fasciitis in a medical center in northern Taiwan: emergence of methicillin-resistant Staphylococcus aureus in the community.

The prognosis of NF caused by CA-MRSA was good after adequate surgical and antimicrobial treatment, and glycopeptides may be prescribed as an empirical treatment until susceptibility results.

Community-acquired methicillin-resistant Staphylococcus aureus emerging as an important cause of necrotizing fasciitis.

It is reasonable to administer empiric MRSA coverage for NF in endemic locations given the propensity of PVL-positive CA-MRSA to cause severe necrotizing infections, and community-acquired MRSA is an important cause of NF in region.

Necrotizing fasciitis caused by methicillin-resistant Staphylococcus aureus resulting in death. A report of three cases.

Severe soft-tissue infection caused by methicillin-resistant Staphylococcus aureus appears to be an emerging clinical entity with a poor prognosis that requires aggressive treatment, and Miller et al. were the first to describe community-acquired necrotizing f as an emerging hazard.

Necrotizing Fasciitis and Methicillin Resistant Staphylococcus Aureus

There was male predominance in NF by MRSA in patients treated for NF, and lesions on extremities had better prognosis similar results were shown in other study.

Retrospective study of necrotizing fasciitis and characterization of its associated Methicillin-resistant Staphylococcus aureus in Taiwan

BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) has emerged as a prevalent pathogen of necrotizing fasciitis (NF) in Taiwan. A four-year NF cases and clinical and genetic differences

Fulminant necrotising fasciitis by community-acquired methicillin-resistant Staphylococcus aureus

This case underscores that CA-MRSA, while rarely reported, can cause a fulminant presentation of NF similar to GAS in immunocompetent patients.

Monomicrobial necrotizing fasciitis caused by coagulase-negative Staphylococci and methicillin-resistant Staphylococcus aureus

Diabetic patients with a history of abrasion injury or chronic ulcer should be cautioned about the risk of developing CoNS and MRSA necrotizing fasciitis, and should be considered to be serious as that caused by MRSA.

Community-acquired methicillin-resistant Staphylococcus aureus necrotizing fasciitis in a healthy adolescent male.

A case of CA-MRSA necrotizing fasciitis is presented in a previously healthy 11-year-old male with no risk factors and is presented as a potentially life-threatening infection in the U.S. pediatric population.



Determinants of mortality for necrotizing soft-tissue infections.

Early debridement of NSTi was associated with a significant decrease in mortality, and S. pyogenes infection was the most common cause of monomicrobial NSTI, but was not associated with an increased mortality.

Clinical and microbiological features of necrotizing fasciitis

The microbiological and clinical characteristics of 83 patients with necrotizing fasciitis treated over a period of 17 years are presented, highlighting the polymicrobial nature of NF.

The microbiology of necrotizing soft tissue infections.

A Case of Subacute Necrotizing Fasciitis

A 48‐year‐old woman who developed necrotizing groin fasciitis with insidious onset was referred to us because of high fever, an ulcer on the left labium majus, and a cellulitis‐like lesion with severe pain on the lower abdomen.

The etiology of bacterial cellulitis as determined by fine-needle aspiration.

According to these data the optimal initial therapy for bacterial cellulitis in adults should be with drugs active against both staphylococci and streptococci.

Necrotizing Soft-Tissue Infections

&NA; Necrotizing fasciitis is a rare and often fatal soft-tissue infection involving the superficial fascial layers of the extremities, abdomen, or perineum. Necrotizing fasciitis typically begins

High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections.

In this urban ED population, MRSA is a major pathogen in skin and soft tissue infections and should be considered when empiric antibiotic therapy is selected for such infections.

Necrotizing soft tissue infections: a primary care review.

  • A. Headley
  • Medicine, Biology
    American family physician
  • 2003
No single organism or combination of organisms is consistently responsible for necrotizing soft tissue infections; most infections are polymicrobial, with both anaerobic and aerobic bacteria frequently present.

Life-threatening hemoptysis in adults with community-acquired pneumonia due to Panton-Valentine leukocidin-secreting Staphylococcus aureus

Three new consecutive cases of life-threatening hemoptysis in adults with community-acquired pneumonia due to Panton-Valentine leukocidin-secreting Staphylococcus aureus are presented, focusing on