• DOI:10.1056/NEJMOA042683
• Corpus ID: 27903087

Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles.

@article{Miller2005NecrotizingFC,
  title={Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles.},
  author={Loren G. Miller and Françoise Perdreau-Remington and Gunter K. Rieg and Sheherbano Mehdi and Joshua Perlroth and Arnold S Bayer and Angela W. Tang and Tieu O Phung and Brad Spellberg},
  journal={The New England journal of medicine},
  year={2005},
  volume={352 14},
  pages={
          1445-53
        }
}

• L. Miller, F. Perdreau-Remington, +6 authors B. Spellberg
• Published 7 April 2005
• Medicine, Biology
• The New England journal of medicine

BACKGROUND
Necrotizing fasciitis is a life-threatening infection requiring urgent surgical and medical therapy. Staphylococcus aureus has been a very uncommon cause of necrotizing fasciitis, but we have recently noted an alarming number of these infections caused by community-associated methicillin-resistant S. aureus (MRSA).

METHODS
We reviewed the records of 843 patients whose wound cultures grew MRSA at our center from January 15, 2003, to April 15, 2004. Among this cohort, 14 were identified as patients presenting from the community with clinical and intraoperative findings of necrotizing fasciitis, necrotizing myositis, or both.

RESULTS
The median age of the patients was 46 years (range, 28 to 68), and 71 percent were men. Coexisting conditions or risk factors included current or past injection-drug use (43 percent); previous MRSA infection, diabetes, and chronic hepatitis C (21 percent each); and cancer and human immunodeficiency virus infection or the acquired immunodeficiency syndrome (7 percent each). Four patients (29 percent) had no serious coexisting conditions or risk factors. All patients received combined medical and surgical therapy, and none died, but they had serious complications, including the need for reconstructive surgery and prolonged stay in the intensive care unit. Wound cultures were monomicrobial for MRSA in 86 percent, and 40 percent of patients (4 of 10) for whom blood cultures were obtained had positive results. All MRSA isolates were susceptible in vitro to clindamycin, trimethoprim-sulfamethoxazole, and rifampin. All recovered isolates belonged to the same genotype (multilocus sequence type ST8, pulsed-field type USA300, and staphylococcal cassette chromosome mec type IV [SCCmecIV]) and carried the Panton-Valentine leukocidin (pvl), lukD, and lukE genes, but no other toxin genes were detected.

CONCLUSIONS
Necrotizing fasciitis caused by community-associated MRSA is an emerging clinical entity. In areas in which community-associated MRSA infection is endemic, empirical treatment of suspected necrotizing fasciitis should include antibiotics predictably active against this pathogen.