Necrotic cell death and neurodegeneration

@article{Troulinaki2012NecroticCD,
  title={Necrotic cell death and neurodegeneration},
  author={Kostoula Troulinaki and Nektarios Tavernarakis},
  journal={Worm},
  year={2012},
  volume={1},
  pages={176 - 181}
}
Necrosis, one of the two main types of cell death, contributes critically in many devastating pathological conditions in human, including stroke, ischemia, trauma and neurodegenerative diseases. However, unlike apoptosis, the molecular mechanisms underlying necrotic cell death and neurodegeneration are poorly understood. Caenorhabditis elegans offers a powerful platform for a thorough and systematic dissection of the molecular basis of necrotic cell death. Similarly to humans, neuronal necrosis… 

Necrotic Cell Death in Caenorhabditis elegans

TLDR
This chapter surveys necrosis paradigms that have been characterized in the nematode and outlines the cellular and molecular mechanisms implicated in mediating cell demise, and discusses experimental approaches that utilize C. elegans to elucidate the molecular underpinnings of devastating human disorders that entail necrosis.

Necrotic cell death in Caenorhabditis elegans.

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TLDR
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