Necrosis versus apoptosis as the mechanism of target cell death induced by Entamoeba histolytica.

@article{Berninghausen1997NecrosisVA,
  title={Necrosis versus apoptosis as the mechanism of target cell death induced by Entamoeba histolytica.},
  author={Otto Berninghausen and Matthias Leippe},
  journal={Infection and immunity},
  year={1997},
  volume={65 9},
  pages={3615-21}
}
The human pathogen Entamoeba histolytica is known to kill a variety of host cells, including leukocytes. Using human myeloid cells as targets, we studied whether cytotoxicity of amoebic trophozoites in vitro is equivalent to the induction of apoptosis or whether these target cells die via necrosis. Based upon morphological criteria, incubation of target cells with amoebae resulted in necrosis, with cell swelling, rupture of plasma membrane, and release of cell contents including nucleic acids… CONTINUE READING

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Amoebapores. Parasitol. Today 13:178–183

  • M. Leippe
  • 1997

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