Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin.

@article{Mikes2007NecrosisPI,
  title={Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin.},
  author={Jaromir Mikes and J{\'a}n Kleban and Veronika Sa{\vc}kov{\'a} and Viktor Horv{\'a}th and Erika M{\'a}ria Jamborov{\'a} and Alena Hyr{\vs}lov{\'a} Vaculov{\'a} and Alois Kozub{\'i}k and Jiřina Hofmanov{\'a} and Peter Fedoro{\vc}ko},
  journal={Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology},
  year={2007},
  volume={6 7},
  pages={758-66}
}
Photodynamic therapy (PDT) represents a new rapidly-developing anticancer approach based on administration of a non- or weakly-toxic photosensitizer and its activation with light of appropriate wavelength. Hypericin, one of the promising photosensitizers, is known to induce apoptosis with high efficiency in various cell line models. However, here we report the prevalence of necrosis accompanied by suppression of caspase-3 activation in colon adenocarcinoma HT-29 cells exposed to an extensive… CONTINUE READING
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