• Corpus ID: 39359585

Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance.

  title={Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance.},
  author={Jeffrey W. Searle and John F. R. Kerr and C. J. Bishop},
  journal={Pathology annual},
  volume={17 Pt 2},
Therapeutische Immunmodulation der Interaktion dendritischer Zellen und CD4+ T Zellen bei Ischaemie-Reperfusion der Leber
It is demonstrated for the first time that hepatic DCs interact with CD4 T cells in the postischemic liver in vivo and modulation of DCs and/or generation of tolerogenic DCs attenuates intrahepaticCD4 T-cell recruitment and reduces I/R injury.
A simple method for accurate estimation of apoptotic cells.
  • N. Singh
  • Biology
    Experimental cell research
  • 2000
A simple, sensitive, and reliable "DNA diffusion" assay for the quantification of apoptosis is described, using human lymphocytes and human lymphoblastoid cells exposed to 0, 12.5, 25, 50, or 100 rad of X-rays as in previous studies.
Activation-associated necrosis in human immunodeficiency virus infection.
Lymphocytes from HIV-infected persons are defective in their ability to synthesize nucleotides via this pathway, indicating one possible mechanism for the activation-associated necrosis seen in HIV infection.
Breast Cancer Cell Line , MDA-MB-468 Programmed Cell Death in an Estrogen-independent Human Updated
Results indicate that MDA-MB-468 estrogen-independent human mammary carcinoma cells retain the ability to undergo programmed cell death after treatment with cytotoxic drugs that induce a "thymineless" state.
Apoptosis in the development of the immune system: Growth factors, clonal selection and bcl-2
The molecular analysis of apoptosis now takes a high priority and the protooncogene bcl-2 appears to be responsible for specific suppression of apoptotic activity in several important situations.
Apoptosis and Glomerular Injury After Prolonged Nitric Oxide Synthase Inhibition in Spontaneously Hypertensive Rats
Results indicate that angiotensin II activation, induced by L-NAME, was related to glomerular cell deletion and apoptosis together with the pathophysiological changes of severe nephrosclerosis and impaired renal dynamics.
An Essential Role of the NF-κB/Toll-Like Receptor Pathway in Induction of Inflammatory and Tissue-Repair Gene Expression by Necrotic Cells1
It is shown that necrotic cells, but not apoptotic cells, activate NF-κB and induce expression of genes involved in inflammatory and tissue-repair responses, including neutrophil-specific chemokine genes KC and macrophage-inflammatory protein-2, in viable fibroblasts and macocytes.
Change in the frequency of apoptosis after low‐ and high‐dose X‐irradiation of human lymphocytes
The results of this study indicate that the vast majority of peripheral blood lymphocytes are radioresistant.
Cell Viability Assessment Using Fluorescence Vital Dyes and Confocal Microscopy in Evaluating Freezing and Thawing Protocols Used in Cryopreservation of Allogeneic Venous Grafts
The authors present their contribution to the improvement of methods suitable for the detection of the freezing and thawing damage of cells of cryopreserved venous grafts used for lower limb revascularization procedures, which found the mean and median immediate post-thaw viability values above 70% were found in using both thawed protocols and both types of cutting.