Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response.

@article{Festjens2006NecrosisAW,
  title={Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response.},
  author={Nele Festjens and Tom Vanden Berghe and Peter Vandenabeele},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1757 9-10},
  pages={
          1371-87
        }
}
Necrosis has long been described as a consequence of physico-chemical stress and thus accidental and uncontrolled. Recently, it is becoming clear that necrotic cell death is as well controlled and programmed as caspase-dependent apoptosis, and that it may be an important cell death mode that is both pathologically and physiologically relevant. Necrotic cell death is not the result of one well-described signalling cascade but is the consequence of extensive crosstalk between several biochemical… CONTINUE READING
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