Necroptosis contributes to the NMDA-induced excitotoxicity in rat's cultured cortical neurons.

@article{Li2008NecroptosisCT,
  title={Necroptosis contributes to the NMDA-induced excitotoxicity in rat's cultured cortical neurons.},
  author={Yanli Li and Xiaorong Yang and Cun-gen Ma and Jiantian Qiao and Ce Zhang},
  journal={Neuroscience letters},
  year={2008},
  volume={447 2-3},
  pages={120-3}
}
Necroptosis is a newly discovered type of cell death characterized with the combined biochemical and ultrastructural features of necrosis and apoptosis. Nec-1 has been reported to exhibit the selective inhibition for necroptosis, which has now been used as an operational definition of necroptosis. The purpose of this study was to evaluate whether necroptosis is involved in the NMDA-induced excitotoxicity and furthermore whether the elevation of intracellular Ca(2+) is involved in the NMDA… CONTINUE READING

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