Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death

  title={Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death},
  author={Jason Karch and Onur Kanisicak and Matthew J. Brody and Michelle A. Sargent and Demetria M. Michael and Jeffery D Molkentin and D. Jaya Chandra},
  booktitle={PloS one},
During apoptosis the pro-death Bcl-2 family members Bax and Bak induce mitochondrial outer membrane permeabilization (MOMP) to mediate cell death. Recently, it was shown that Bax and Bak are also required for mitochondrial permeability transition pore (MPTP)-dependent necrosis, where, in their non-oligomeric state, they enhance permeability characteristics of the outer mitochondrial membrane. Necroptosis is another form of regulated necrosis involving the death receptors and receptor… CONTINUE READING


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Proceedings of the National Academy of Sciences of the United States of America • 2013
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