Necrobiotic xanthogranuloma.

  title={Necrobiotic xanthogranuloma.},
  author={David Ali Mehregan and Richard K. Winkelmann},
  journal={Archives of dermatology},
  volume={128 1},
We reviewed 32 cases of necrobiotic xanthogranuloma and 16 cases from the world literature. Necrobiotic xanthogranuloma is a destructive dermal and subcutaneous xanthogranuloma that most frequently involves the face (periorbital region) and trunk. Monoclonal gammopathy is common (IgG-kappa in 23 cases and IgG-lambda in nine cases), and cryoglobulins have also been found. Low complement levels, anemia, and leukopenia are frequently present. Bone marrow examination shows plasma cell proliferation… CONTINUE READING
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