Neck rotation and neck mimic docking in the noncatalytic Kar3-associated protein Vik1.

@article{Duan2012NeckRA,
  title={Neck rotation and neck mimic docking in the noncatalytic Kar3-associated protein Vik1.},
  author={Da Duan and Zhimeng Jia and Monika Joshi and Jacqueline Brunton and Michelle Siu-Lin Chan and Doran Drew and Darlene Davis and John S Allingham},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 48},
  pages={40292-301}
}
BACKGROUND Kar3Vik1 is a heterodimeric kinesin with one catalytic subunit (Kar3) and one noncatalytic subunit (Vik1). RESULTS Vik1 experiences conformational changes in regions analogous to the force-producing elements in catalytic kinesins. CONCLUSION A molecular mechanism by which Kar3 could trigger Vik1's release from microtubules was revealed. SIGNIFICANCE These findings will serve as the prototype for understanding the motile mechanism of kinesin-14 motors in general. It is widely… CONTINUE READING