Neck Linker Length Determines the Degree of Processivity in Kinesin-1 and Kinesin-2 Motors

@article{Shastry2010NeckLL,
  title={Neck Linker Length Determines the Degree of Processivity in Kinesin-1 and Kinesin-2 Motors},
  author={Shankar Shastry and William O. Hancock},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={939-943}
}
Defining the mechanical and biochemical determinates of kinesin processivity is important for understanding how diverse kinesins are tuned for specific cellular functions. Because transmission of mechanical forces through the 14-18 amino acid neck linker domain underlies coordinated stepping, we investigated the role of neck linker length, charge, and structure in kinesin-1 and kinesin-2 motor behavior. For optimum comparison with kinesin-1, the KIF3A head and neck linker of kinesin-2 were… CONTINUE READING

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