Necessity of IgE antibodies and mast cells for manifestation of resistance against larval Haemaphysalis longicornis ticks in mice.

@article{Matsuda1990NecessityOI,
  title={Necessity of IgE antibodies and mast cells for manifestation of resistance against larval Haemaphysalis longicornis ticks in mice.},
  author={Hikaru Matsuda and Naohiro Watanabe and Yasuo Kiso and Seiichi Hirota and Hiroko Ushio and Yasuyuki Kannan and Miyuki Azuma and Hideki Koyama and Yukihiko Kitamura},
  journal={Journal of immunology},
  year={1990},
  volume={144 1},
  pages={259-62}
}
Genetically mast cell-deficient WBB6F1-W/Wv mice showed an apparent defect in manifestation of the resistance against larval Haemaphysalis longicornis ticks, but their serum IgE levels increased more than 100-fold after the second tick infestation. Immune sera obtained from the WBB6F1-W/Wv mice were adoptively transferred to the other WBB6F1-W/Wv mice which had received intracutaneous injections of WBB6F1-+/+ mouse-derived cultured mast cells. Because the resistance against ticks was detectable… CONTINUE READING

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