Necessity and sufficiency of beta interferon for nitric oxide production in mouse peritoneal macrophages.

@article{Zhang1994NecessityAS,
  title={Necessity and sufficiency of beta interferon for nitric oxide production in mouse peritoneal macrophages.},
  author={Xuan Zhang and E. Roberts Alley and Stephen William Russell and David C. Morrison},
  journal={Infection and immunity},
  year={1994},
  volume={62 1},
  pages={
          33-40
        }
}
Bacterial lipopolysaccharide and some cytokines can activate macrophages to secrete nitric oxide. Macrophage-derived nitric oxide is a key cytotoxic factor for microbicidal and tumoricidal processes. We report here that a monoclonal antibody specific for beta interferon inhibited lipopolysaccharide-induced nitric oxide production in thioglycolate-elicited C3HeB/FeJ peritoneal macrophages and macrophage-like cell line RAW 264.7. In addition, exogenous added beta interferon enabled… CONTINUE READING

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