Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1.

@article{Taniura1998NecdinAP,
  title={Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1.},
  author={Hideo Taniura and Naoyuki Taniguchi and Mitsunobu Hara and Kana Yoshikawa},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 2},
  pages={720-8}
}
Necdin is a nuclear protein expressed in virtually all postmitotic neurons, and ectopic expression of this protein strongly suppresses the proliferation of NIH3T3 cells. Simian virus 40 large T antigen targets both p53 and the retinoblastoma protein (Rb) for cellular transformation. By analogy with the interactions of the large T antigen with these nuclear growth suppressors, we examined the ability of necdin to bind to the large T antigen. Necdin was co-immunoprecipitated with the large T… CONTINUE READING

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