Necator americanus: the Na-ASP-2 protein secreted by the infective larvae induces neutrophil recruitment in vivo and in vitro.

@article{Bower2008NecatorAT,
  title={Necator americanus: the Na-ASP-2 protein secreted by the infective larvae induces neutrophil recruitment in vivo and in vitro.},
  author={Molly A. Bower and Stephanie L Constant and Susana Barbosa M{\'e}ndez},
  journal={Experimental parasitology},
  year={2008},
  volume={118 4},
  pages={569-75}
}
The L3-secreted Ancylostoma Secreted Protein-2 from the human hookworm Necator americanus (Na-ASP-2) has been selected as a candidate vaccine antigen in anticipation of clinical trials. Its crystal structure revealed that Na-ASP-2 has structural and charge similarities to CC-chemokines, suggesting that it might act as a chemokine mimic when released by the infective larvae during tissue migration. Using the air pouch model of acute inflammation, we found that Na-ASP-2 induced a significant… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Progress in the development of a recombinant vaccine for human hookworm disease : the Human Hookworm Vaccine Initiative

P. Vilk
International Journal for Parasitology • 2003

Similar Papers

Loading similar papers…