Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma.

@article{Serra2012NebulizedLP,
  title={Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma.},
  author={Magda Fr{\'a}guas Serra and Edna A Anjos-Valotta and P C Olsen and Gina C Couto and Patricia Barbosa Jurgilas and Amanda Costa Cotias and Camila R R P{\~a}o and Tatiana Paula Teixeira Ferreira and Ana Carolina S. de Arantes and Ana L{\'u}cia Pires and Renato S B Cordeiro and Patr{\'i}cia Machado Rodrigues e Silva and Marco Aur{\'e}lio Martins},
  journal={Anesthesiology},
  year={2012},
  volume={117 3},
  pages={580-91}
}
BACKGROUND Evidence suggests that nebulized lidocaine is beneficial in asthma therapy, but to what extent and the mechanisms underlying this effect remain poorly understood. The aim of this study was to assess the impact of lidocaine treatment using a murine model of allergic asthma characterized by expression of pivotal features of the disease: inflammation, mucus production, and lung remodeling. METHODS A/J mice sensitized with ovalbumin were treated with inhaled lidocaine or vehicle… CONTINUE READING