Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis.

Abstract

Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.

Cite this paper

@article{Ruijgrok2006NebulizedAB, title={Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis.}, author={Elisabeth J. Ruijgrok and Marcel H Fens and Irma A. J. M. Bakker-Woudenberg and Els W M van Etten and Arnold Vulto}, journal={Antimicrobial agents and chemotherapy}, year={2006}, volume={50 5}, pages={1852-4} }