Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features.

@article{Dailey2003NebulizationOB,
  title={Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features.},
  author={Lea Ann Dailey and Thomas Schmehl and Tobias Gessler and Matthias Wittmar and Friedrich Grimminger and Werner Seeger and Thomas R. Kissel},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2003},
  volume={86 1},
  pages={131-44}
}
Nanoparticles may be effective drug delivery systems for use in various pulmonary therapeutic schemes. This study investigated the effect of nebulization technology and nanoparticle characteristics on the features of aerosol generation. Suspensions of biodegradable nanoparticles consisting of commercially available poly(lactide-co-glycolide) and novel comb polymers were nebulized with a jet, ultrasonic, and piezo-electric crystal nebulizer. The effects of the nanoparticle suspensions on the… CONTINUE READING
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