Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients.

@article{Pasini2008NebivololTR,
  title={Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients.},
  author={A. Pasini and U. Garbin and C. Stranieri and V. Boccioletti and C. Mozzini and S. Manfro and Mattia Cominacini and L. Cominacini},
  journal={American journal of hypertension},
  year={2008},
  volume={21 11},
  pages={
          1251-7
        }
}
  • A. Pasini, U. Garbin, +6 authors L. Cominacini
  • Published 2008
  • Medicine
  • American journal of hypertension
  • BACKGROUND This study was conducted to evaluate (i) the effect of nebivolol, a selective beta1-adrenergic receptor antagonist, on plasma concentration of asymmetric dimethylarginine (ADMA) and on flow-mediated dilation (FMD) in essential hypertensive patients; (ii) the effect of serum derived from the treated hypertensive patients on ADMA and on dimethylarginine dimethylaminohydrolase 2 (DDAH2), the enzyme that selectively degrades ADMA, in human umbilical vein endothelial cells (HUVECs… CONTINUE READING
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