Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation

@article{Pasini2005NebivololDO,
  title={Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation},
  author={A. Pasini and U. Garbin and M. C. Nava and C. Stranieri and A. Davoli and T. Sawamura and V. L. Cascio and L. Cominacini},
  journal={Journal of Hypertension},
  year={2005},
  volume={23},
  pages={589–596}
}
  • A. Pasini, U. Garbin, +5 authors L. Cominacini
  • Published 2005
  • Medicine
  • Journal of Hypertension
    • Objective To obtain further insight into the mechanism underlying the vasodilator effect of nebivolol. Since oxidative inactivation of nitric oxide (NO) is regarded as an important cause of its decreased biological activity, we studied (1) the effect of nebivolol on some oxidative parameters in essential hypertensive patients; (2) the effect of plasma of nebivolol-treated patients on reactive oxygen species production and NO availability in endothelial cells. Methods A total of 20 healthy… CONTINUE READING
    View on Wolters Kluwer
    ncbi.nlm.nih.gov
    111 Citations
    Background Citations
    31
    Methods Citations
    2
    Results Citations
    2

    Paper Mentions

    Interventional Clinical Trial
    Comparison of Nebivolol and Metoprolol With Exercise and Angiotensin II in Hypertensive Patients
    The purpose of this study is to determine if Nebivolol a) attenuates the angiotensin II (Ang II)-induced increase in oxidative stress, thereby attenuating Ang II-induced… Expand
    ConditionsHypertension
    InterventionDrug, Procedure
    University of Texas Southwestern Medical Center
    April 2009 - June 2013
    111 Citations
    Citation Type

    Citation Type

    Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients.
    • 77
    • PDF
    Nebivolol and metoprolol: long-term effects on inflammation and oxidative stress in essential hypertension
    • M. Serg, P. Kampus, +5 authors J. Eha
    • Chemistry, Medicine
    • Scandinavian journal of clinical and laboratory investigation
    • 2012
    • 31
    Protective effects of nebivolol from oxidative stress to prevent hypertension-related target organ damage
    • 13
    • PDF
    The effect of nebivolol treatment on oxidative stress and antioxidant status in patients with cardiac syndrome-X
    • 29
    Effect of DL-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells.
    • 48
    Beneficial effects of nebivolol treatment on oxidative stress parameters in patients with slow coronary flow.
    • A. Akçay, G. Acar, +4 authors C. Tuncer
    • Medicine
    • Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
    • 2010
    • 16
    • PDF
    Effect of sulfhydryl and non-sulfhydryl angiotensin-converting enzyme inhibitors on endothelial function in essential hypertensive patients.
    • 60
    • PDF
    Evaluation of Effects of Losartan and Nebivolol on Oxidative Stress Parameters in Dialysis Patients
    • 2020
    • PDF
    Nebivolol Reduces Nitroxidative Stress and Restores Nitric Oxide Bioavailability in Endothelium of Black Americans
    • 178
    Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients
    • 180

    References

    SHOWING 1-10 OF 46 REFERENCES
    Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation.
    • 77
    • PDF
    Nebivolol Prevents Vascular NOS III Uncoupling in Experimental Hyperlipidemia and Inhibits NADPH Oxidase Activity in Inflammatory Cells
    • 145
    • PDF
    Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients
    • 100
    Nebivolol decreases systemic oxidative stress in healthy volunteers.
    • 81
    Nebivolol Reverses Endothelial Dysfunction in Essential Hypertension: A Randomized, Double-Blind, Crossover Study
    • 293
    Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
    • 565
    • PDF
    Increased Oxidative Stress and Platelet Activation in Patients With Hypertension and Renovascular Disease
    • 210
    Low-density lipoprotein oxidation in essential hypertension
    • 88
    Nebivolol: a third-generation beta-blocker that augments vascular nitric oxide release: endothelial beta(2)-adrenergic receptor-mediated nitric oxide production.
    • 220
    • PDF
    ADMA and oxidative stress.
    • 393