Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation

@article{Pasini2005NebivololDO,
  title={Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation},
  author={A. Pasini and U. Garbin and M. C. Nava and C. Stranieri and A. Davoli and T. Sawamura and V. L. Cascio and L. Cominacini},
  journal={Journal of Hypertension},
  year={2005},
  volume={23},
  pages={589–596}
}
  • A. Pasini, U. Garbin, +5 authors L. Cominacini
  • Published 2005
  • Medicine
  • Journal of Hypertension
  • Objective To obtain further insight into the mechanism underlying the vasodilator effect of nebivolol. Since oxidative inactivation of nitric oxide (NO) is regarded as an important cause of its decreased biological activity, we studied (1) the effect of nebivolol on some oxidative parameters in essential hypertensive patients; (2) the effect of plasma of nebivolol-treated patients on reactive oxygen species production and NO availability in endothelial cells. Methods A total of 20 healthy… CONTINUE READING
    111 Citations

    Paper Mentions

    Interventional Clinical Trial
    The purpose of this study is to determine if Nebivolol a) attenuates the angiotensin II (Ang II)-induced increase in oxidative stress, thereby attenuating Ang II-induced… Expand
    ConditionsHypertension
    InterventionDrug, Procedure
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