Nebivolol Ameliorates Cisplatin-Induced Nephrotoxicity in Rats.

  title={Nebivolol Ameliorates Cisplatin-Induced Nephrotoxicity in Rats.},
  author={M A Morsy and Gehan Hussein Heeba},
  journal={Basic & clinical pharmacology & toxicology},
  volume={118 6},
Treatment with cisplatin is associated with dose-limiting side effects, mainly nephrotoxicity. On the other hand, nebivolol, a β1 -adrenoceptor antagonist, exhibits vasodilatory and antioxidative properties. This study aimed to determine whether nebivolol possesses a protective effect against cisplatin nephrotoxicity and explore many mechanisms underlying this potential effect. Nephrotoxicity was induced in Wistar rats by a single intraperitoneal injection of cisplatin (6 mg/kg) on day 2… CONTINUE READING