Nebivolol: Endothelium‐Mediated Vasodilating Effect

@article{Ritter2001NebivololEV,
  title={Nebivolol: Endothelium‐Mediated Vasodilating Effect},
  author={J. Ritter},
  journal={Journal of Cardiovascular Pharmacology},
  year={2001},
  volume={38},
  pages={S13–S16}
}
  • J. Ritter
  • Published 2001
  • Medicine
  • Journal of Cardiovascular Pharmacology
Summary: Nebivolol, a racemic mixture of (S,R,R,R) and (R,S,S,S) enantiomers, is the most &bgr;1‐selective adrenoceptor antagonist currently available for clinical use. However, its haemodynamic effects differ from those of classical &bgr;‐adrenoceptor antagonists as a result of a vasodilating action. Nebivolol is devoid of &agr;‐adrenergic antagonist actions, and the detailed mechanism of its vasodilator action is unknown. Nebivolol relaxes precontracted strips of canine coronary and carotid… Expand
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