Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice.

@article{Baumhaekel2008NebivololBN,
  title={Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice.},
  author={Magnus Baumhaekel and Nils Schlimmer and Kansu B{\"u}y{\"u}kafşar and Onur Arikan and Michael B{\"o}hm},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={325 3},
  pages={
          818-23
        }
}
To determine the effects and underlying mechanisms of treatment with the beta-receptor blockers nebivolol and metoprolol on penile endothelial function in apolipoprotein E (ApoE)-/- mice, wild-type (WT) and ApoE-/- mice were fed with a cholesterol-rich diet for 7 weeks. ApoE-/- mice were treated with nebivolol (10 mg/kg/day) or metoprolol (90 mg/kg/day). Endothelial function of aortic and corpora cavernosal tissue was assessed by pharmacological stimulation with carbachol (endothelium dependent… CONTINUE READING

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