Nearest-neighbor thermodynamics of deoxyinosine pairs in DNA duplexes

  title={Nearest-neighbor thermodynamics of deoxyinosine pairs in DNA duplexes},
  author={Norman E. Watkins and J. SantaLucia},
  journal={Nucleic Acids Research},
  pages={6258 - 6267}
Nearest-neighbor thermodynamic parameters of the 'universal pairing base' deoxyinosine were determined for the pairs I.C, I.A, I.T, I.G and I.I adjacent to G.C and A.T pairs. Ultraviolet absorbance melting curves were measured and non-linear regression performed on 84 oligonucleotide duplexes with 9 or 12 bp lengths. These data were combined with data for 13 inosine containing duplexes from the literature. Multiple linear regression was used to solve for the 32 nearest-neighbor unknowns. The… CONTINUE READING


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