Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

@article{Hjberg2008NearNO,
  title={Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes},
  author={Patricia V. H{\o}jberg and Mette Zander and Tina Vilsb{\o}ll and Filip Krag Knop and Thure Krarup and Aage V{\o}lund and Jens Juul Holst and S. Madsbad},
  journal={Diabetologia},
  year={2008},
  volume={51},
  pages={632-640}
}
Aims/hypothesisThe ability of glucagon-like peptide-1 (GLP-1) to enhance beta cell responsiveness to i.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near normalisation of blood glucose (BG) improves the potentiation of glucose-stimulated insulin secretion by GLP-1.MethodsNine obese patients with type 2 diabetes and inadequate glycaemic control (HbA1c 8.0 ± 0.4%) were investigated before and after 4 weeks of… CONTINUE READING

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