Near-infrared photosensitizer based on a cycloimide derivative of chlorin p6: 13,15-N-(3'-hydroxypropyl)cycloimide chlorin p6.

@article{Feofanov2002NearinfraredPB,
  title={Near-infrared photosensitizer based on a cycloimide derivative of chlorin p6: 13,15-N-(3'-hydroxypropyl)cycloimide chlorin p6.},
  author={Alexei V. Feofanov and Alexei Grichine and Tatyana A Karmakova and Anna D Pljutinskaya and Victoria Lebedeva and Anna Filyasova and Raisa I. Yakubovskaya and Andrei D. Mironov and Marguerite Egret-Charlier and Paul Vigny},
  journal={Photochemistry and photobiology},
  year={2002},
  volume={75 6},
  pages={
          633-43
        }
}
The 13,15-N-(3'-hydroxypropylcycloimide) chlorin p6 (CIC), which absorbs at 711 nm, possesses considerable photoinduced cell-killing activity. It is 43-, 61- and 110-fold more active than chlorin p6, 3-formyl-3-devinyl chlorin p6 and Photogem, respectively, and has no cytotoxicity without irradiation as estimated on A549 human adenocarcinoma cells. To attain the highest intracellular penetration and activity the monomeric form of CIC should be stabilized. This stabilization in an aqueous… CONTINUE READING