Near infrared laser‐tissue welding using nanoshells as an exogenous absorber

@article{Gobin2005NearIL,
  title={Near infrared laser‐tissue welding using nanoshells as an exogenous absorber},
  author={Andre Gobin and D. Patrick O'Neal and Daniel M Watkins and Naomi J. Halas and Rebekah A. Drezek and Jennifer L. West},
  journal={Lasers in Surgery and Medicine},
  year={2005},
  volume={37}
}
BACKGROUND AND OBJECTIVE Gold nanoshells are a new class of nanoparticles that can be designed to strongly absorb light in the near infrared (NIR. [] Key Method Optimization work was performed on ex vivo muscle samples and then translated into testing in an in vivo rat skin wound-healing model. Mechanical testing of the muscle samples was immediately performed and compared to intact tissue mechanical properties.
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New advancements in the biomedical exploitation of near-infrared absorbing gold nanoparticles as an original solution for the photothermal closure of surgical incisions are reviewed.
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The ability to ablate tumor cells in vitro and efficacy for photothermal cancer therapy is demonstrated, and an in vivo model shows significantly increased long-term, tumor-free survival.
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TLDR
It was demonstrated that laser soldering using combination of ICG + GNs could be practical provided the optothermal properties of the tissue are carefully optimized and the tensile strength of soldered skin is higher than skins that soldered with only ICG or GNs.
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Despite the recent progress in creating photothermal agents of various compositions and morphologies, there is a strong need to further develop photothermal transducers that absorb light in the
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TLDR
The observation of a reshaping and associated blue shift of the NIR absorption band of GNRs after laser treatment supports the occurrence of a self-terminating process, and thus of additional safety of the minimally invasive laser procedure.
Gold Nanoshells in Biomedical Applications
TLDR
The sections in this article are Physical Properties of Gold Nanoshells, Synthesis and Bioconjugation, Biodistribution, Toxicity Profile and Transport, and Biomedical Applications.
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