Near infrared laser‐tissue welding using nanoshells as an exogenous absorber

  title={Near infrared laser‐tissue welding using nanoshells as an exogenous absorber},
  author={Andre Gobin and D. Patrick O'Neal and Daniel M Watkins and Naomi J. Halas and Rebekah A. Drezek and Jennifer L. West},
  journal={Lasers in Surgery and Medicine},
BACKGROUND AND OBJECTIVE Gold nanoshells are a new class of nanoparticles that can be designed to strongly absorb light in the near infrared (NIR. [] Key Method Optimization work was performed on ex vivo muscle samples and then translated into testing in an in vivo rat skin wound-healing model. Mechanical testing of the muscle samples was immediately performed and compared to intact tissue mechanical properties.
Emerging concepts of laser-activated nanoparticles for tissue bonding.
New advancements in the biomedical exploitation of near-infrared absorbing gold nanoparticles as an original solution for the photothermal closure of surgical incisions are reviewed.
Subtissue Imaging and Thermal Monitoring of Gold Nanorods through Joined Encapsulation with Nd-Doped Infrared-Emitting Nanoparticles.
Encapsulation of gold nanorods together with Nd-doped fluorescent nanoparticles in a biocompatible polymer creates multifunctional nanostructures, whose infrared fluorescence allows their
Photothermal effects in connective tissues mediated by laser-activated gold nanorods.
Hybrid nanocomposite films for laser‐activated tissue bonding
The adhesive effect as a function of pulse power and duration is investigated and an optimal operative window to achieve effective and reproducible welds with minimal detrimental superheating is identified.
Near-infrared-resonant gold/gold sulfide nanoparticles as a photothermal cancer therapeutic agent.
The ability to ablate tumor cells in vitro and efficacy for photothermal cancer therapy is demonstrated, and an in vivo model shows significantly increased long-term, tumor-free survival.
Enhanced laser tissue soldering using indocyanine green chromophore and gold nanoshells combination.
It was demonstrated that laser soldering using combination of ICG + GNs could be practical provided the optothermal properties of the tissue are carefully optimized and the tensile strength of soldered skin is higher than skins that soldered with only ICG or GNs.
Gold nanorod-decorated multiwalled carbon nanotubes for near-infrared photothermal therapy
Despite the recent progress in creating photothermal agents of various compositions and morphologies, there is a strong need to further develop photothermal transducers that absorb light in the
In vivo carotid artery closure by laser activation of hyaluronan-embedded gold nanorods.
The observation of a reshaping and associated blue shift of the NIR absorption band of GNRs after laser treatment supports the occurrence of a self-terminating process, and thus of additional safety of the minimally invasive laser procedure.
Gold Nanoshells in Biomedical Applications
The sections in this article are Physical Properties of Gold Nanoshells, Synthesis and Bioconjugation, Biodistribution, Toxicity Profile and Transport, and Biomedical Applications.


Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
  • L. HirschR. Stafford J. West
  • Engineering
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
In vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage, and found good correlation with histological findings.
Dye‐enhanced laser welding for skin closure
IG dye‐enhanced laser welding is possible in skin and with further optimization may have practical application, and there was an optimal range of irradiances for “welding,” which varied inversely with dye concentration.
Nanoshell-Enabled Photonics-Based Imaging and Therapy of Cancer
How the core/shell ratio and overall size of a nanoshell influences its scattering and absorption properties is illustrated and several examples ofnanoshell-based diagnostic and therapeutic approaches are described including the development of Nanoshell bioconjugates for molecular imaging, the use of scattering nanosells as contrast agents for optical coherence tomography (OCT), and the use for absorbing nanoshels in NIR thermal therapy of tumors.
Carotid artery anastomosis with albumin solder and near infrared lasers: A comparative study
Laser tissue‐welding has been used for anastomosis of carotid arteries and effects on tissue damage were studied in vitro and in vivo.
Infrared extinction properties of gold nanoshells
Gold nanoshells, nanoparticles consisting of a silica core coated with a thin gold shell, exhibit a strong optical resonance that depends sensitively on their core radius and shell thickness. Gold
Effects of endogenous absorption in human albumin solder for acute laser wound closure
Human albumin is currently being used as a biological solder in laser tissue welding and the effects of differing albumin concentrations on wound closure when a 1.32 μm Nd:YAG laser is used to repair skin incisions.
Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery.
Significantly enhanced drug release from composite hydrogels has been achieved in response to irradiation by light at 1064 nm and the nanoshell-composite hydrogel can release multiple bursts of protein in responseto repeated near-IR irradiation.
Skin closure with dye-enhanced laser welding and fibrinogen.
This work compared the closure of skin incisions by two different dye-enhanced, fibrinogen-based laser welding systems [argon laser (power density 4.78 W/cm2) with fluorescein i].
Laser skin welding: In vivo tensile strength and wound healing results
Laser skin welding was investigated as a general model for laser tissue closure. Scanned delivery of near‐infrared laser radiation in combination with a dye can produce strong welds with limited