Near-infrared fluorescence imaging of HER-2 protein over-expression in tumour cells

@article{Hilger2004NearinfraredFI,
  title={Near-infrared fluorescence imaging of HER-2 protein over-expression in tumour cells},
  author={I. Hilger and Yvonne Leistner and Alexander Berndt and Christine Fritsche and Karl Michael Haas and Hartwig Kosmehl and Werner A. Kaiser},
  journal={European Radiology},
  year={2004},
  volume={14},
  pages={1124-1129}
}
The aim of this study was to evaluate in vitro and in vivo imaging of HER-2-over-expressing tumours using near-infrared optical imaging. A fluorochrome probe was designed by coupling Cy5.5 to anti-HER-2 antibodies. Cells over-expressing (SK-BR-3 cells) or normally expressing (PE/CA-PJ34 cells) the HER-2 protein were incubated with the probe. After removing unbound probe molecules, fluorescence intensities were determined (a.u.: arbitrary units). Cells were additionally investigated using FACS… CONTINUE READING
26 Citations
21 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Trastuzumab: a review of its use in the treatment of metastatic breast cancer overexpressing HER2

  • K McKeage, CM Perry
  • Drugs
  • 2002
1 Excerpt

Similar Papers

Loading similar papers…