Near death from a novel synthetic opioid labeled U-47700: emergence of a new opioid class

@article{Schneir2017NearDF,
  title={Near death from a novel synthetic opioid labeled U-47700: emergence of a new opioid class},
  author={Aaron B. Schneir and Imir G. Metushi and Christian M Sloane and David J Benaron and Robert L. Fitzgerald},
  journal={Clinical Toxicology},
  year={2017},
  volume={55},
  pages={51 - 54}
}
Abstract Background: In the last decade there has been a worldwide surge in the recreational abuse of novel psychoactive substances, particularly amphetamine derivatives and synthetic cannabinoids. Synthetic opioids such as AH-7921, MT-45, and U-47700, with structures distinct from those ever used therapeutically or described recreationally, have also recently emerged. Case details: We report a patient who suffered respiratory failure and depressed level of consciousness after recreationally… 
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92 Citations
Highly Influential Citations
4
Background Citations
12
Methods Citations
4

92 Citations

Novel synthetic opioids: A review of the literature
Misuse of Novel Synthetic Opioids: A Deadly New Trend
TLDR
Novel synthetic opioids (NSOs) include various analogs of fentanyl and newly emerging non-fentanyl compounds and there is strong demand for their use, these drugs are being trafficked by organized crime.
U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market
TLDR
The evidence demonstrates that U-47700 is a potent μ-opioid receptor agonist, which poses a serious risk for overdosing and death, however, most analogs of U- 47700 appear to be less potent and have been detected infrequently in forensic specimens.
Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse
TLDR
It is suggested that the patient, who demonstrated an interest and use of synthetic agents, likely ingested a BZD derivative, and should be considered in patients with drug abuse and an unknown source of a positive BzD screen on urine immunoassay.
Confirmation of Carfentanil, U-47700 and Other Synthetic Opioids in a Human Performance Case by LC-MS-MS.
TLDR
This case demonstrates the need to supplement routine toxicological analyses with a sensitive methodology that can detect synthetic opioids in human performance cases where opioid use may be implicated and first report of a DUI cases where carfentanil, U-47700 and other synthetic opioids were confirmed and described in a human performance blood sample.
Analysis of U-47700, a Novel Synthetic Opioid, in Human Urine by LC-MS-MS and LC-QToF.
TLDR
Findings suggest that U-47700 drug may cause significant morbidity and mortality within the United States as an emerging drug threat.
Pharmacotoxicology of Non-fentanyl Derived New Synthetic Opioids
A class of opioid agonists not structurally related to fentanyl, derived from research publications of pharmaceutical companies or patents within the United States and abroad are contributing to the…
Another fatal case related to the recreational abuse of U-47700
TLDR
A non-targeted liquid chromatography/mass spectrometry (LC/MS)-based screening approach of urine and cerebrospinal fluid samples after intravenous injection of trans-3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide (U-47700) shows that the powder had a relatively high purity and was adulterated to a low degree.
Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review
Near‐fatal Intoxication with the “New” Synthetic Opioid U‐47700: The First Reported Case in the Czech Republic
TLDR
A case of near‐fatal U‐47700 intoxication of a man found unconscious (with drug powder residues) is reported, after 40 h in hospital (including 12 h of supported ventilation), he recovered and was discharged.
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