Near death from a novel synthetic opioid labeled U-47700: emergence of a new opioid class

  title={Near death from a novel synthetic opioid labeled U-47700: emergence of a new opioid class},
  author={Aaron B. Schneir and Imir G. Metushi and Christian M Sloane and David J Benaron and Robert L. Fitzgerald},
  journal={Clinical Toxicology},
  pages={51 - 54}
Abstract Background: In the last decade there has been a worldwide surge in the recreational abuse of novel psychoactive substances, particularly amphetamine derivatives and synthetic cannabinoids. Synthetic opioids such as AH-7921, MT-45, and U-47700, with structures distinct from those ever used therapeutically or described recreationally, have also recently emerged. Case details: We report a patient who suffered respiratory failure and depressed level of consciousness after recreationally… 
Misuse of Novel Synthetic Opioids: A Deadly New Trend
Novel synthetic opioids (NSOs) include various analogs of fentanyl and newly emerging non-fentanyl compounds and there is strong demand for their use, these drugs are being trafficked by organized crime.
U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market
The evidence demonstrates that U-47700 is a potent μ-opioid receptor agonist, which poses a serious risk for overdosing and death, however, most analogs of U- 47700 appear to be less potent and have been detected infrequently in forensic specimens.
Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse
It is suggested that the patient, who demonstrated an interest and use of synthetic agents, likely ingested a BZD derivative, and should be considered in patients with drug abuse and an unknown source of a positive BzD screen on urine immunoassay.
Confirmation of Carfentanil, U-47700 and Other Synthetic Opioids in a Human Performance Case by LC-MS-MS.
This case demonstrates the need to supplement routine toxicological analyses with a sensitive methodology that can detect synthetic opioids in human performance cases where opioid use may be implicated and first report of a DUI cases where carfentanil, U-47700 and other synthetic opioids were confirmed and described in a human performance blood sample.
Analysis of U-47700, a Novel Synthetic Opioid, in Human Urine by LC-MS-MS and LC-QToF.
Findings suggest that U-47700 drug may cause significant morbidity and mortality within the United States as an emerging drug threat.
Pharmacotoxicology of Non-fentanyl Derived New Synthetic Opioids
A class of opioid agonists not structurally related to fentanyl, derived from research publications of pharmaceutical companies or patents within the United States and abroad are contributing to the
Another fatal case related to the recreational abuse of U-47700
A non-targeted liquid chromatography/mass spectrometry (LC/MS)-based screening approach of urine and cerebrospinal fluid samples after intravenous injection of trans-3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide (U-47700) shows that the powder had a relatively high purity and was adulterated to a low degree.
Near‐fatal Intoxication with the “New” Synthetic Opioid U‐47700: The First Reported Case in the Czech Republic
A case of near‐fatal U‐47700 intoxication of a man found unconscious (with drug powder residues) is reported, after 40 h in hospital (including 12 h of supported ventilation), he recovered and was discharged.


AH-7921: the list of new psychoactive opioids is expanded
AH-7921 is a current public health risk, and better international collaboration, effective legislation and continuous community alertness are needed to tackle this current growing problem.
[MT-45--a dangerous and potentially ototoxic internet drug].
Clinical data from 12 analytically confirmed hospital cases of MT-45 poisoning demonstrate thatMT-45, like other opioids, can induce potentially life threatening respiratory depression and loss of consciousness in users and that symptoms are usually reversed by standard doses of the opioid receptor antagonist naloxone.
Fatal intoxications associated with the designer opioid AH-7921.
It is reasonable to assume that no sharp dividing line exists between lethal and non-lethal concentrations, and deaths with AH-7921 seem to occur both at low and high concentrations, probably a result of different tolerance to the drug.
The first reported fatality associated with the synthetic opioid 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and implications for forensic analysis.
The search for synthetic opioids as alternatives to opium-based derivatives has provided an important impulse to drug development around the globe, but the exploration of these important discoveries has also been increasingly mined by largescale producers of these materials, which are then offered for sale.
Lethal poisonings with AH-7921 in combination with other substances.
MT-45, a new psychoactive substance associated with hearing loss and unconsciousness
MT-45 should be added to the growing list of harmful NPS causing life-threatening poisonings, and rapid actions taken to make it a controlled substance.
U-50,488 and the к receptor: A personalized account covering the period 1973 to 1990
U-50,488 provided a succinct template for structural modifications and they are described for the period up to 1990 and a description of the structural classes of K agonists is provided including a summary of K recognition sites based on known agonists.
U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990.
  • J. Szmuszkovicz
  • Biology
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1999
U-50,488 provided a succinct template for structural modifications and they are described for the period up to 1990 and a description of the structural classes of kappa agonists is provided including a summary ofKappa recognition sites based on known agonists.