Near death from a novel synthetic opioid labeled U-47700: emergence of a new opioid class
@article{Schneir2017NearDF, title={Near death from a novel synthetic opioid labeled U-47700: emergence of a new opioid class}, author={Aaron B. Schneir and Imir G. Metushi and Christian M Sloane and David J Benaron and Robert L. Fitzgerald}, journal={Clinical Toxicology}, year={2017}, volume={55}, pages={51 - 54} }
Abstract Background: In the last decade there has been a worldwide surge in the recreational abuse of novel psychoactive substances, particularly amphetamine derivatives and synthetic cannabinoids. Synthetic opioids such as AH-7921, MT-45, and U-47700, with structures distinct from those ever used therapeutically or described recreationally, have also recently emerged. Case details: We report a patient who suffered respiratory failure and depressed level of consciousness after recreationally…
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References
SHOWING 1-10 OF 23 REFERENCES
AH-7921: the list of new psychoactive opioids is expanded
- ChemistryForensic Toxicology
- 2015
AH-7921 is a current public health risk, and better international collaboration, effective legislation and continuous community alertness are needed to tackle this current growing problem.
[MT-45--a dangerous and potentially ototoxic internet drug].
- MedicineLakartidningen
- 2014
Clinical data from 12 analytically confirmed hospital cases of MT-45 poisoning demonstrate thatMT-45, like other opioids, can induce potentially life threatening respiratory depression and loss of consciousness in users and that symptoms are usually reversed by standard doses of the opioid receptor antagonist naloxone.
Fatal intoxications associated with the designer opioid AH-7921.
- MedicineJournal of analytical toxicology
- 2014
It is reasonable to assume that no sharp dividing line exists between lethal and non-lethal concentrations, and deaths with AH-7921 seem to occur both at low and high concentrations, probably a result of different tolerance to the drug.
The first reported fatality associated with the synthetic opioid 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and implications for forensic analysis.
- ChemistryDrug testing and analysis
- 2016
The search for synthetic opioids as alternatives to opium-based derivatives has provided an important impulse to drug development around the globe, but the exploration of these important discoveries has also been increasingly mined by largescale producers of these materials, which are then offered for sale.
Lethal poisonings with AH-7921 in combination with other substances.
- Medicine, ChemistryForensic science international
- 2014
Next generation of novel psychoactive substances on the horizon - A complex problem to face.
- BiologyDrug and alcohol dependence
- 2015
MT-45, a new psychoactive substance associated with hearing loss and unconsciousness
- MedicineClinical toxicology
- 2014
MT-45 should be added to the growing list of harmful NPS causing life-threatening poisonings, and rapid actions taken to make it a controlled substance.
A case of acute intoxication due to combined use of fentanyl and 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700).
- ChemistryForensic science international
- 2016
U-50,488 and the к receptor: A personalized account covering the period 1973 to 1990
- Biology
- 1999
U-50,488 provided a succinct template for structural modifications and they are described for the period up to 1990 and a description of the structural classes of K agonists is provided including a summary of K recognition sites based on known agonists.
U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990.
- BiologyProgress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
- 1999
U-50,488 provided a succinct template for structural modifications and they are described for the period up to 1990 and a description of the structural classes of kappa agonists is provided including a summary ofKappa recognition sites based on known agonists.