Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction.

  title={Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction.},
  author={Xing Zhang and Ethan C. Settembre and Chen Xu and Philip Ralph Dormitzer and Richard John Bellamy and Stephen C Harrison and Nikolaus Grigorieff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 6},
Electron cryomicroscopy (cryo-EM) yields images of macromolecular assemblies and their components, from which 3D structures can be determined, by using an image processing method commonly known as "single-particle reconstruction." During the past two decades, this technique has become an important tool for 3D structure determination, but it generally has not been possible to determine atomic models. In principle, individual molecular images contain high-resolution information contaminated by a… CONTINUE READING
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