Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction.


Electron cryomicroscopy (cryo-EM) yields images of macromolecular assemblies and their components, from which 3D structures can be determined, by using an image processing method commonly known as "single-particle reconstruction." During the past two decades, this technique has become an important tool for 3D structure determination, but it generally has… (More)
DOI: 10.1073/pnas.0711623105


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